Gnas.site - GNAS gene: MedlinePlus Genetics

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WEBThe GNAS gene provides instructions for making one component, the stimulatory alpha subunit, of a protein complex called a guanine nucleotide-binding protein (G protein). Learn about this gene and related health conditions.

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GNAS gene: MedlinePlus Genetics
medlineplus.gov

https://medlineplus.gov/genetics/gene/gnas/

WEBThe GNAS gene provides instructions for making one component, the stimulatory alpha subunit, of a protein complex called a guanine nucleotide-binding protein (G protein). Learn about this gene and related health conditions.

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GNAS Gene - GeneCards | GNAS3 Protein | GNAS3 Antibody
genecards.org

https://www.genecards.org/cgi-bin/carddisp.pl?gene=GNAS

WEBApr 3, 2024 · GNAS (GNAS Complex Locus) is a Protein Coding gene. Diseases associated with GNAS include Mccune-Albright Syndrome and Osseous Heteroplasia, Progressive. Among its related pathways are ADORA2B mediated anti-inflammatory cytokines production and GPCR Pathway.

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GNAS complex locus - Wikipedia
wikipedia.org

https://en.wikipedia.org/wiki/GNAS_complex_locus

WEBGNAS complex locus is a gene locus in humans. Its main product is the heterotrimeric G-protein alpha subunit G s-α, a key component of G protein-coupled receptor-regulated adenylyl cyclase signal transduction pathways. GNAS stands for Guanine Nucleotide binding protein, Alpha Stimulating activity polypeptide.

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Disorders of GNAS Inactivation - GeneReviews® - NCBI Bookshelf
nih.gov

https://www.ncbi.nlm.nih.gov/books/NBK459117/

WEBOct 26, 2017 · A disorder of GNAS inactivation should be suspected in individuals with the following phenotypes. Pseudohypoparathyroidism Ia (PHP-Ia) and pseudohypoparathyroidism Ic (PHP-Ic). The most readily recognized form of PHP is PHP-Ia, which has clinical and endocrine features similar to PHP-Ic.

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Minireview: GNAS : Normal and Abnormal Functions - Oxford …
oup.com

https://academic.oup.com/endo/article/145/12/5459/2499741

WEBDec 1, 2004 · GNAS is a complex imprinted gene that uses multiple promoters to generate several gene products, including the G protein α-subunit (G s α) that couples seven-transmembrane receptors to the cAMP-generating enzyme adenylyl cyclase.

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GNAS spectrum of disorders - PMC - National Center for …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417430/

WEBThe GNAS gene, located on the long arm of chromosome 20 in humans [ 1 ], gives rise to multiple gene products, including transcripts that encode the alpha-subunit of the stimulatory guanine nucleotide-binding protein (Gsα), extra-large Gsα (XLαs), and neuroendocrine secretory protein 55 (NESP55) [ 2 – 5] ( Fig. 1 ).

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Obesity-Associated GNAS Mutations and the Melanocortin Pathway
nejm.org

https://www.nejm.org/doi/full/10.1056/NEJMoa2103329

WEBOct 6, 2021 · Conclusions. Because pathogenic mutations may manifest with obesity alone, screening of children with severe obesity for GNAS deficiency may allow early diagnosis, improving clinical outcomes,...

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GNAS shifts metabolism in pancreatic cancer - Nature
nature.com

https://www.nature.com/articles/s41556-018-0120-5

WEBJun 25, 2018 · Concurrent G-protein α s (GNAS) and KRAS mutations in a subset of pancreatic tumours are now shown to inhibit SIK kinases through aberrant cAMP–PKA activation, triggering a metabolic...

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GNAS locus: bone related diseases and mouse models
frontiersin.org

https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1255864/full

WEBOct 17, 2023 · The GNAS locus, encompassing Gsα, XLαs, and other products, exerts profound influence over a variety of physiological processes through regulating multitude signaling pathways. Among these, the regulation on …

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GNAS locus: bone related diseases and mouse models - PMC
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10619756/

WEBOct 18, 2023 · The GNAS locus, encompassing Gsα, XLαs, and other products, exerts profound influence over a variety of physiological processes through regulating multitude signaling pathways. Among these, the regulation on …

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