Metal- and Oxidant-Free Green Three-Component
https://pubs.acs.org/doi/10.1021/acs.joc.1c02313
Nov 26, 2021 . A metal- and oxidant-free three-component desulfurization and deamination condensation of amidines, isothiocyanates, and hydrazines for the synthesis of structurally diverse fully substituted 1H-1,2,4-triazol-3-amines is described. The reaction proceeds without the requirement of any external catalysts, metals, ligands, or oxidants. This [2 + 1 + 2] cyclization strategy involves C–N and C ...
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