Keyword Analysis & Research: jsmd194

clinicaltrials.gov

https://classic.clinicaltrials.gov/ct2/show/NCT03502577

Actual Enrollment : 19 participants Study Type : Interventional (Clinical Trial) Intervention Model: Single Group Assignment

Actual Enrollment : 19 participants

Study Type : Interventional (Clinical Trial)

Intervention Model: Single Group Assignment

DA: 30 PA: 13 MOZ Rank: 99 Up or Down: Up

onclive.com

https://www.onclive.com/view/fda-approved-car-t-cell-therapies-illuminate-advances-in-multiple-myeloma

WEBMay 9, 2022 · The Fred [Hutchinson Cancer Research Center] presented [data on] a CAR product that includes [JSMD194] which is an upregulator for BCMA. BCMA is the target toward which all CAR T cells are...

DA: 73 PA: 41 MOZ Rank: 31 Up or Down: Up

ashpublications.org

https://ashpublications.org/blood/article/138/Supplement%201/551/479409/Safety-and-Efficacy-of-Fully-Human-BCMA-CAR-T

WEBNov 5, 2021 · Following lymphodepleting chemotherapy, BCMA CAR T cells were infused at a starting dose of 5 x 10 7 CAR+ cells, in combination with JSMD194 dosed orally at 25 … Author: Andrew J. Cowan, Andrew J. Cowan, Margot Pont, Blythe Duke Sather, Cameron J. Turtle, Brian G. Till,... Publish Year: 2019

Author: Andrew J. Cowan, Andrew J. Cowan, Margot Pont, Blythe Duke Sather, Cameron J. Turtle, Brian G. Till,...

Publish Year: 2019

DA: 86 PA: 45 MOZ Rank: 65 Up or Down: Up

ashpublications.org

https://ashpublications.org/blood/article/134/Supplement_1/1856/427564/Response-to-Bcma-CAR-T-Cells-Correlates-with

WEBNov 13, 2019 · Two patients have been evaluated for response to an JSMD194 after failing other BCMA targeted agents. One received a prior BCMA CAR-T cell product and after … Author: Damian J. Green, Damian J. Green, Margot Pont, Andrew J. Cowan, Andrew J. Cowan, Gabriel O Cole, Bly... Publish Year: 2019

Author: Damian J. Green, Damian J. Green, Margot Pont, Andrew J. Cowan, Andrew J. Cowan, Gabriel O Cole, Bly...

Publish Year: 2019

DA: 74 PA: 50 MOZ Rank: 78 Up or Down: Up

nature.com

https://www.nature.com/articles/s41571-020-0427-6

WEBSep 25, 2020 · Patients continued to receive JSMD194 three times a week for 3 weeks following CAR T cell infusion 40. A median 20-fold increase … Author: Lekha Mikkilineni, James N. Kochenderfer Publish Year: 2021

Author: Lekha Mikkilineni, James N. Kochenderfer

Publish Year: 2021

DA: 26 PA: 7 MOZ Rank: 21 Up or Down: Up

sciencedirect.com

https://www.sciencedirect.com/science/article/pii/S000649712102543X

WEBNov 23, 2021 · We have completed accrual to a phase 1 first-in-human trial of escalating doses of BCMA targeted CAR T cells in combination with a GSI (JSMD194) for patients …

DA: 99 PA: 43 MOZ Rank: 65 Up or Down: Up

ashpublications.org

https://ashpublications.org/blood/article/134/Supplement_1/204/426104/Efficacy-and-Safety-of-Fully-Human-Bcma-CAR-T

WEBNov 13, 2019 · To assess the discreet impact of the GSI on plasma cell BCMA expression, patients received a GSI (JSMD194) monotherapy "run-in" involving three oral doses (25 …

DA: 93 PA: 21 MOZ Rank: 15 Up or Down: Up

sciencedirect.com

https://www.sciencedirect.com/science/article/pii/S0006497118581222

WEBNov 13, 2019 · In this study we demonstrate that gamma secretase inhibition with JSMD194 routinely increases BCMA surface density on myeloma cells in treated patients and …

DA: 68 PA: 83 MOZ Rank: 22 Up or Down: Up

trialbulletin.com

https://trialbulletin.com/lib/entry/ct-03502577

WEBApr 11, 2018 · JSMD194 may enhance the killing of cancer cells by increasing the BCMA expression on multiple myeloma cells, making the targeted BCMA CAR-T treatment …

DA: 54 PA: 74 MOZ Rank: 31 Up or Down: Up

researchgate.net

https://www.researchgate.net/publication/356502633_Safety_and_Efficacy_of_Fully_Human_BCMA_CAR_T_Cells_in_Combination_with_a_Gamma_Secretase_Inhibitor_to_Increase_BCMA_Surface_Expression_in_Patients_with_Relapsed_or_Refractory_Multiple_Myeloma

WEBNov 5, 2021 · Following lymphodepleting chemotherapy, BCMA CAR T cells were infused at a starting dose of 5 x 10 7 CAR+ cells, in combination with JSMD194 dosed orally at 25 …

DA: 64 PA: 20 MOZ Rank: 15 Up or Down: Up