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What is fetroja ® (cefiderocol) used for?

Fetroja ® (cefiderocol) is indicated in patients 18 years of age or older for the treatment of complicated urinary tract infections (cUTIs), including pyelonephritis caused by the following susceptible Gram-negative microorganisms: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and Enterobacter cloacae complex.

What is the mechanism of action of fetroja?

Mechanism of Action. Fetroja is a cephalosporin antibacterial with activity against Gram-negative aerobic bacteria. Cefiderocol functions as a siderophore and binds to extracellular free (ferric) iron.

Is fetroja contraindicated?

Fetroja is contraindicated in patients with a known history of severe hypersensitivity to cefiderocol or other beta-lactam antibacterial drugs, or any other component of Fetroja.

What is the molecular formula of fetroja?

The molecular formula is 3C 30 H 34 ClN 7 O 10 S 2 ∙4C 7 H 8 O 3 S∙H 2 SO 4 ∙xH 2 O. Fetroja for injection is a white to off-white, sterile, lyophilized powder formulated with 1 gram of cefiderocol (equivalent to 1.6 grams of cefiderocol sulfate tosylate), sucrose (900 mg), sodium chloride (216 mg), and sodium hydroxide to adjust pH.

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