b022 | B022 | NIK Inhibitor

Keyword	CPC	PCC	Volume	Score	Length of keyword
b022	1.54	0.9	7821	43	4

Keyword	CPC	PCC	Volume	Score
b0229	0.5	0.7	946	42
b0223	1.37	0.8	5241	23
b0228	0.16	0.4	6893	86
b0222	0.36	0.8	5821	32
b0221	0.89	0.1	3074	62
b0224g	1.77	0.3	8141	91
b02272490	1.99	1	8912	98
b0228-05	0.36	1	7960	80
b022-u08-ip	0.44	0.9	8132	6
b0229 icd 10	0.69	1	6925	35
b0229 chevy silverado	1.68	0.3	756	70
b022 classe di concorso	0.2	1	2083	1
b0229 code	0.46	0.8	4225	81
b0229107	0.77	0.2	2463	85
b0229306	1.14	0.2	9174	10
b0229 code gm	0.52	0.8	8749	47
b02296	1.9	0.4	3266	68
b0229126	2	0.5	1785	29
b0229299	1.07	0.2	740	15
b0229411	1.13	0.1	8809	93
b02295	1.42	0.9	4041	46
b0229303	1.56	0.3	7113	27
b0229 chevy	0.22	0.8	7167	66
b0229 code chevy	1.74	0.2	9130	9
b0223102	1.85	0.1	8730	4
b0223 code	0.86	0.8	3553	73
b0223-61	1.41	0.9	693	60
b02230043	0.42	0.1	9457	3

Search Results related to b022 on Search Engine

B022 | NIK Inhibitor | MedChemExpress
medchemexpress.com

https://www.medchemexpress.com/b022.html

WEBB022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor (Ki of 4.2 nM; IC50=15.1 nM). B022 protects liver from toxin-induced inflammation, oxidative stress, and injury. B022 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide …

DA: 1 PA: 62 MOZ Rank: 48 Up or Down: Up

A small-molecule inhibitor of NF-κB-inducing kinase (NIK ... - PubMed
nih.gov

https://pubmed.ncbi.nlm.nih.gov/27871061/

WEBB022 inhibited the NIK signaling pathway, including NIK-induced p100-to-p52 processing and inflammatory gene expression, both in vitro and in vivo Furthermore, in vivo administration of B022 protected against not only NIK but also CCl 4-induced liver inflammation and injury. Our data suggest that inhibition of NIK is a novel strategy for ...

DA: 42 PA: 39 MOZ Rank: 32 Up or Down: Up

ICD-10-CM Code B02.2 - Zoster with other nervous system …
icd.codes

https://icd.codes/icd10cm/B022

WEBThe ICD code B022 is used to code Postherpetic neuralgia. Postherpetic neuralgia is a nerve pain due to damage caused by the varicella zoster virus. Typically, the neuralgia is confined to a dermatomic area of the skin, and follows an outbreak of herpes zoster (commonly known as shingles) in that same dermatomic area.

DA: 9 PA: 90 MOZ Rank: 46 Up or Down: Up

Structure-based optimization of indoline-containing
sciencedirect.com

https://www.sciencedirect.com/science/article/pii/S0022286023018458

WEBJan 5, 2024 · B022 is yellow, NIK is grey, and key residues are in sticks. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.) The structure of B022 features a conjugation scaffold of 2-aminopyrimidine and indoline, which were readily assembled via a S N Ar reaction [18] .

DA: 78 PA: 89 MOZ Rank: 83 Up or Down: Up

Targeting NF-κB-Inducing Kinase (NIK) in Immunity, …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696043/

WEBNov 11, 2020 · Consistent with that finding, pharmacological inhibition of NIK with B022 attenuated ethanol-induced hepatic steatosis and suppression of PPARα and fatty acid oxidation [46,62]. With regard to obesity, increased adiposity induces recruitment of pro-inflammatory M1 macrophages that are classically activated by LPS and INF-γ, and …

DA: 16 PA: 52 MOZ Rank: 23 Up or Down: Up

Frontiers | The Therapeutic Potential of Targeting NIK in B Cell
frontiersin.org

https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.930986/full

WEBJul 11, 2022 · The commercially available NIK inhibitor B022, which is structurally very similar to Amgen16, was the first small molecule inhibitor targeting NIK to be applied in in vivo models . Using this inhibitor, Ren et al. showed inhibition of p100-to-p52 processing and utilized a liver-specific NIK overexpression mouse model.

DA: 26 PA: 48 MOZ Rank: 38 Up or Down: Up

EDA2R–NIK signalling promotes muscle atrophy linked to
nature.com

https://www.nature.com/articles/s41586-023-06047-y

WEBMay 10, 2023 · In fact, B022 treatment also blocked the EDA-A2-induced mobility shift of NIK protein whereas the original NIK signal was massively enhanced, possibly due to a negative feedback loop severed by ...

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Product Data Sheet - MedchemExpress.com
medchemexpress.com

https://file.medchemexpress.com/batch_PDF/HY-120501/B022-DataSheet-MedChemExpress.pdf

WEBB022 is a click chemistry reagent, it contains an Alkyne group. and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. B022 (0-5 μM; 12 hours; Hepa1 cells) treatment suppresses NIK-induced p52 formation in a dose-dependent manner[1]. and CXCL5[1]. hyperglycemia[3].

DA: 79 PA: 69 MOZ Rank: 46 Up or Down: Up

A small‐molecule inhibitor of NF‐κB‐inducing kinase (NIK) …
wiley.com

https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.201600840R

WEBNov 8, 2016 · In this study, a small-molecule inhibitor of NIK, B022, was found to be a potent and selective chemical probe for liver inflammation and injury. B022 inhibited the NIK signaling pathway, including NIK-induced p100-to-p52 processing and inflammatory gene expression, both in vitro and in vivo.

DA: 74 PA: 58 MOZ Rank: 11 Up or Down: Up

B022 | NF-κB | TargetMol
targetmol.com

https://www.targetmol.com/compound/B022

WEBB022 is a selective and potent NF-κB-induced kinase (NIK) inhibitor (Ki: 4.2 nM), a chemical probe for the treatment of liver inflammation and injury.B022 protects the liver from inflammation and injury caused by oxidative stress and toxins. B022 treatment of Hepa1 cells (0 μM, 0.5 μM, 5 μM; 12 hours) can suppress NIK-induced p52 formation ...

DA: 63 PA: 4 MOZ Rank: 3 Up or Down: Up